AIH/PSC Overlap Syndrome
Does anyone else have experience of this? it seems quite hard to find information as this combination is very rare. I've plodded through several learned articles in recent weeks, none of which are hugely optimistic.
The plan at present for me is a further biopsy in a few weeks, then to start immunosuppressants.When all this began for me - over a decade ago, it looked like I had small duct PSC (this has a better prognosis than large duct PSC). Then the sentence was commuted to AIH. Now they think I have both! Over the decade I've been tired and achey but LFTs stabilised, and went to normal briefly, but now it seems treatment is necessary. I have other AI conditions - hypothyroid, dry eyes, probably mild IBD.
I am VERY worried about weight gain on steroids - I am overweight, had been doing well losing weight (the old trick of eating less and moving more ....), but have BMI around 30 and a bit stuck again - lots of joint pain and fatigue and motivation has gone down (winter in northern britain, health uncertainty, etc). I hope I might have a combination of steroid and azathioprine, due to age and fatness (I am early 50s and female so higher risk of osteoporosis) - we'll see. Any knowledge/experiences welcome.